If its a 4 stroke it should be fine, the main thing is the condition of the engine now, if its new or almost new, has clean oil and a good tune up that should be no problem, in fact that will likely be harder on you then the bike. Make sure it has oil, keep the speed reasonable you know like the speed limit and have yourself a good time. If you have not ridden long distance, give yourself some time to build up the stamina, because in the beginning you hang onto the handle bars too tight, and ride too tense, it takes a lot of energy to focus while driving, because you are the pinball on the road and every thing with 4 wheels has the potential to squash you and ruin your day. Semi trucks in particular, can be a severe hazard in some conditions. in more ways than one.
If you do one thing in your life pay attention one hundred percent of the time where that front tire is going to be in the next 100 feet. Never hit anything with the front tire, and I mean anything. The bike has most of the weight on the rear, if the front tire hits anything going Straight ahead, it can knock it sideways (but your body and the bike are still going straight) this can be a real disaster if you are not paying attention. And especially going into a corner, when leaning into a corner, a rock, a coke bottle, a empty soda can are things that can knock the front tire sideways which can drop you on your face instantly.it happens fast too. Its all about paying attention and ride like your invisible to everyone else, do not take for granted everyone sees you or notices you are making a turn. good luck the more practice riding you get, the safer more comfortable the ride will be for you. 250 is a bit light for long distance travel, but it will work, keep the speed reasonable.
I know from experience I had good luck with honda motorcycle and have had several these bikes have a tendency to run forever, unlike kawasaki and suzuki I had some good strong 750 that while a bit top heavy around town with a full tank of gas, were long distance runners when it came to a freeway bike running down the road.